3/10/2024 0 Comments Death scream bloody gore rar![]() PGZ and/or ATRA inhibited significantly the proliferation of both cell lines. The effect of the PPARγ ligand Pioglitazone (PGZ) either in the absence or in the presence of a RAR ligand on the proliferation and apoptosis of glioblastoma cells was examined using two glioblastoma cell lines (N39 and DBTRG05MG). No mutations or polymorphisms of the PPARγ gene were observed in these cell lines. In contrast, glia from nine healthy human brains expressed very low levels of PPARγ. In this study, we have shown that 11 glioblastoma cell lines and nine fresh glioblastoma tissue samples from patients expressed high-levels of PPARγ. Our previous data indicated that the combination of ligands for peroxisome proliferator-activated receptor γ (PPARγ) and retinoic acid receptor (RAR) induces apoptosis of breast cancer cells in vitro and in a murine model. High-grade gliomas are characterized by a rapid proliferation rate, invasiveness and angiogenesis.
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